Heiden, Matthew G Vander: search on Z-Library

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1

Metabolism in the Tumor Microenvironment

Lau, Allison N., Vander Heiden, Matthew G.

Journal:

Annual Review of Cancer Biology

Year:

2020

Language:

english

File:

PDF, 3.77 MB

english, 2020

2

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Lunt, Sophia Y., Vander Heiden, Matthew G.

Journal:

Annual Review of Cell and Developmental Biology

Year:

2011

Language:

english

File:

PDF, 434 KB

english, 2011

3

Understanding the Intersections between Metabolism and Cancer Biology

Vander Heiden, Matthew G., DeBerardinis, Ralph J.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

4

Targeting cancer metabolism: a therapeutic window opens

Vander Heiden, Matthew G.

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 847 KB

english, 2011

5

Pyruvate kinase: Function, regulation and role in cancer

Israelsen, William J., Vander Heiden, Matthew G.

Journal:

Seminars in Cell & Developmental Biology

Year:

2015

Language:

english

File:

PDF, 249 KB

english, 2015

6

Critical Functions of the Lysosome in Cancer Biology

Davidson, Shawn M., Vander Heiden, Matthew G.

Journal:

Annual Review of Pharmacology

Year:

2017

Language:

english

File:

PDF, 670 KB

english, 2017

7

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Hu, Jie, Locasale, Jason W, Bielas, Jason H, O'Sullivan, Jacintha, Sheahan, Kieran, Cantley, Lewis C, Heiden, Matthew G Vander, Vitkup, Dennis

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

8

Pyruvate as a Pivot Point for Oncogene-Induced Senescence

Olenchock, Benjamin A., Vander Heiden, Matthew G.

Journal:

Year:

2013

Language:

english

File:

PDF, 262 KB

english, 2013

9

The Reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Bonuccelli, Gloria, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Pavlides, Stephanos, Pestell, Richard G., Fatatis, Alessandro, Witkiewicz, Agnieszka K., Vander Heiden, Matthew G., Migneco, Gemma

Journal:

Year:

2010

Language:

english

File:

PDF, 2.64 MB

english, 2010

10

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex I. Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, Matthew G. Vander Heiden, Jeffrey P.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.02 MB

english, 2010

11

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

Wang, Ying-Hua, Israelsen, William J., Lee, Dongjun, Yu, Vionnie W.C., Jeanson, Nathaniel T., Clish, Clary B., Cantley, Lewis C., Vander Heiden, Matthew G., Scadden, David T.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.24 MB

english, 2014

12

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

Hosios, Aaron M., Hecht, Vivian C., Danai, Laura V., Johnson, Marc O., Rathmell, Jeffrey C., Steinhauser, Matthew L., Manalis, Scott R., Vander Heiden, Matthew G.

Journal:

Developmental Cell

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

13

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Sullivan, Lucas B., Gui, Dan Y., Hosios, Aaron M., Bush, Lauren N., Freinkman, Elizaveta, Vander Heiden, Matthew G.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

14

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.

Journal:

Year:

2017

Language:

english

File:

PDF, 4.61 MB

english, 2017

15

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Martin J. Walsh, Kyle R. Brimacombe, Henrike Veith, James M. Bougie, Thomas Daniel, William Leister, Lewis C. Cantley, William J. Israelsen, Matthew G. Vander Heiden, Min Shen, Douglas S. Auld, Craig

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

16

The Alternative Splicing Repressors hnRNP A1/A2 and PTB Influence Pyruvate Kinase Isoform Expression and Cell Metabolism

Cynthia V. Clower, Deblina Chatterjee, Zhenxun Wang, Lewis C. Cantley, Matthew G. Vander Heiden, Adrian R. Krainer and Tom Maniatis

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

17

PHGDH amplification and altered glucose metabolism in human melanoma

Edouard Mullarky, Katherine R. Mattaini, Matthew G. Vander Heiden, Lewis C. Cantley, Jason W. Locasale

Journal:

Pigment Cell & Melanoma Research

Year:

2011

Language:

english

File:

PDF, 1.43 MB

english, 2011

18

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

Yang, Nicole J., Liu, David V., Sklaviadis, Demetra, Gui, Dan Y., Vander Heiden, Matthew G., Wittrup, K. Dane

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 892 KB

english, 2015

19

Aspartate is an endogenous metabolic limitation for tumour growth

Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Malstrom, Scott, Lewis, Caroline A., Vander Heiden, Matthew G

Journal:

Nature Cell Biology

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

20

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Sivanand, Sharanya, Vander Heiden, Matthew G.

Journal:

Year:

2020

File:

PDF, 1.02 MB

2020

21

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Jian-kang Jiang, Matthew B. Boxer, Matthew G. Vander Heiden, Min Shen, Amanda P. Skoumbourdis, Noel Southall, Henrike Veith, William Leister, Christopher P. Austin, Hee Won Park, James Inglese, Lewis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 855 KB

english, 2010

22

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark A., Olenchock, Benjamin A., Mayers, Jared R., Wasylenko, Thomas M., Vokes, Natalie I., Guarente, Leonard, Heiden, Matthew G. Vander, Stephanopoulos, Gr

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 674 KB

english, 2013

23

Rewiring of glycolysis in cancer cell metabolism

Locasale, Jason W., Vander Heiden, Matthew G., Cantley, Lewis C.

Journal:

Year:

2010

Language:

english

File:

PDF, 106 KB

english, 2010

24

The redox requirements of proliferating mammalian cells

Hosios, Aaron M, Vander Heiden, Matthew G

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 363 KB

english, 2018

25

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn M., Bhutkar, Arjun, Lewis, Caroline A., Bronson, Roderick T., Vander Heiden, Matthew G., Jacks, Tyler

Journal:

Cancer & Metabolism

Year:

2018

Language:

english

File:

PDF, 5.58 MB

english, 2018

26

Metabolic targets for cancer therapy

Galluzzi, Lorenzo, Kepp, Oliver, Heiden, Matthew G. Vander, Kroemer, Guido

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 45 KB

english, 2013

27

2-Hydroxyglutarate Production by Mutant Isocitrate Dehydrogenase is Independent of Substrate Channeling but Sensitive to Compartment-Specific Metabolite Levels

Dexter, Joseph P., Ward, Patrick S., Dasgupta, Tathagata, Hosios, Aaron M., Gunawardena, Jeremy, Heiden, Matthew G. Vander

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 45 KB

english, 2016

28

Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

29

Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation

Diehl, Frances F., Lewis, Caroline A., Fiske, Brian P., Vander Heiden, Matthew G.

Journal:

Nature Metabolism

Year:

2019

Language:

english

File:

PDF, 1.32 MB

english, 2019

30

Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells

Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott

Journal:

Scientific Reports

Year:

2020

File:

PDF, 927 KB

2020

31

10.1038/70237

Vander Heiden, Matthew G., Thompson, Craig B.

Journal:

Nature Cell Biology

Year:

1999

Language:

english

File:

PDF, 503 KB

english, 1999

32

Acetate metabolism in cancer cells

Hosios, Aaron M, Vander Heiden, Matthew G

Journal:

Cancer & Metabolism

Year:

2014

Language:

english

File:

PDF, 177 KB

english, 2014

33

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

Mattaini, Katherine R, Brignole, Edward J, Kini, Mitali, Davidson, Shawn M, Fiske, Brian P, Drennan, Catherine L, Vander Heiden, Matthew G

Journal:

Cancer & Metabolism

Year:

2015

Language:

english

File:

PDF, 3.14 MB

english, 2015

34

Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate

Dexter, Joseph P., Ward, Patrick S., Dasgupta, Tathagata, Hosios, Aaron M., Gunawardena, Jeremy, Vander Heiden, Matthew G.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 5.73 MB

english, 2018

35

Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity

Liu, Vivian M., Howell, Andrea J., Hosios, Aaron M., Li, Zhaoqi, Israelsen, William J., Vander Heiden, Matthew G.

Journal:

Year:

2019

Language:

english

File:

PDF, 3.36 MB

english, 2019

36

Cancer's insatiable appetite

Locasale, Jason W, Cantley, Lewis C, Heiden, Matthew G Vander

Journal:

Nature Biotechnology

Year:

2009

Language:

english

File:

PDF, 154 KB

english, 2009

37

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

Kung, Hsiu-Ni, Marks, Jeffrey R., Chi, Jen-Tsan, Vander Heiden, Matthew G.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.76 MB

english, 2011

38

Identification of small molecule inhibitors of pyruvate kinase M2

Matthew G. Vander Heiden, Heather R. Christofk, Eli Schuman, Alexander O. Subtelny, Hadar Sharfi, Edward E. Harlow, Jun Xian, Lewis C. Cantley

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

39

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

Lewis, Caroline A., Parker, Seth J., Fiske, Brian P., McCloskey, Douglas, Gui, Dan Y., Green, Courtney R., Vokes, Natalie I., Feist, Adam M., Vander Heiden, Matthew G., Metallo, Christian M.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.28 MB

english, 2014

40

PKM2 is not required for pancreatic ductal adenocarcinoma

Hillis, Alissandra L, Lau, Allison N, Devoe, Camille X, Dayton, Talya L, Danai, Laura V, Di Vizio, Dolores, Vander Heiden, Matthew G

Journal:

Cancer & Metabolism

Year:

2018

Language:

english

File:

PDF, 1.72 MB

english, 2018

41

Understanding Metabolic Regulation and Its Influence on Cell Physiology

Metallo, Christian M., Vander Heiden, Matthew G.

Journal:

Year:

2013

Language:

english

File:

PDF, 956 KB

english, 2013

42

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan, Vander Heiden, Matthew G., Jacks, Tyler

Journal:

Cell Metabolism

Year:

2016

Language:

english

File:

PDF, 2.49 MB

english, 2016

43

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, Heather R., Vander Heiden, Matthew G., Harris, Marian H., Ramanathan, Arvind, Gerszten, Robert E., Wei, Ru, Fleming, Mark D., Schreiber, Stuart L., Cantley, Lewis C.

Journal:

Year:

2008

Language:

english

File:

PDF, 488 KB

english, 2008

44

Targeting Metabolism for Cancer Therapy

Luengo, Alba, Gui, Dan Y., Vander Heiden, Matthew G.

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

45

Putting the K+ in K+aloric Restriction

Lien, Evan C., Lau, Allison N., Vander Heiden, Matthew G.

Journal:

Year:

2019

Language:

english

File:

PDF, 966 KB

english, 2019

46

In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

Chen, Jieming, Madireddi, Shravan, Nagarkar, Deepti, Migdal, Maciej, Vander Heiden, Jason, Chang, Diana, Mukhyala, Kiran, Selvaraj, Suresh, Kadel, Edward E, Brauer, Matthew J, Mariathasan, Sanjeev, Hu

Journal:

Briefings in Bioinformatics

Year:

2020

File:

PDF, 342 KB

2020

47

Metabolic targets for cancer therapy

Galluzzi, Lorenzo, Kepp, Oliver, Heiden, Matthew G. Vander, Kroemer, Guido

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 785 KB

english, 2013

48

The Role of Pyruvate Kinase M2 in Cancer Metabolism

Liu, Vivian M., Vander Heiden, Matthew G.

Journal:

Brain Pathology

Year:

2015

Language:

english

File:

PDF, 56 KB

english, 2015

49

Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis

Hosios, Aaron M., Vander Heiden, Matthew G.

Journal:

Developmental Cell

Year:

2017

Language:

english

File:

PDF, 209 KB

english, 2017

50

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Liu, Tong, Kuwana, Tomomi, Zhang, Hongkai, Vander Heiden, Matthew G., Lerner, Richard A., Newmeyer, Donald D., Ron, David

Journal:

Year:

2019

Language:

english

File:

PDF, 10.70 MB

english, 2019

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